Mayo River Vacations from $307

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The Latest Mayo River vacation packages

Price found within the past 48 hours. Click for updated prices.
OYO Inn Kernersville

OYO Inn Kernersville

2.5 out of 5
Price was $357, price is now $307 per person
$307
per person
May 8 - May 11
found 13 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
7/10 Good! (369 reviews)
Room was fine for price the price they asked at hotel was too high but water was very hot and was great for shower...book online for a decent rate

Reviewed on Jan 6, 2026

The Historic Magnolia House

The Historic Magnolia House

3.5 out of 5
Price was $669, price is now $525 per person
$525
per person
May 15 - May 18
found 13 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
6/10 (2 reviews)
O.Henry Hotel

O.Henry Hotel

4 out of 5
Price was $772, price is now $629 per person
$629
per person
May 15 - May 18
found 13 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
9.8/10 Exceptional! (724 reviews)
The room was beautifully appointed and perfectly clean. It was absolutely quiet, allowing us a wonderful night's sleep. The staff was friendly and helpful.

Reviewed on Feb 11, 2026

Proximity Hotel

Proximity Hotel

4 out of 5
Price was $740, price is now $626 per person
$626
per person
May 15 - May 18
found 13 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
9.6/10 Exceptional! (879 reviews)
Second time my husband and I had a weekend getaway here and it was great. The room was spacious and the bathroom with the wet room was amazing. Everyone there is super kind and polite and goes out of their way to make your stay a good one. I hope we’ll go back next year!

Reviewed on Feb 21, 2026

Hyatt Place Greensboro

Hyatt Place Greensboro

3 out of 5
Price was $481, price is now $420 per person
$420
per person
May 8 - May 11
found 13 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
7.8/10 Good! (1,001 reviews)
Staff was very friendly and breakfast was very good. If you stay, ask for rooms facing the front to avoid interstate traffic noise.

Reviewed on Feb 21, 2026

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Discover the most popular places to visit in Mayo River

The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.

Reynolds Homestead

You can study the exhibits at Reynolds Homestead, a museum with a story of its own, during your travels to Patrick Springs. Amble around the area's forest or visit its spas.

Reynolds Homestead

Mayo River Hotel Deals

The Lodge at Primland, Auberge Collection

The Lodge at Primland, Auberge Collection

5 out of 5
2000 Busted Rock Rd Meadows Of Dan VA
$485 nightly
The price is $545 total per night from Mar 2 to Mar 3
$545 total
Mar 2 - Mar 3
Total with taxes and fees
9.2/10 Wonderful! (27 reviews)
Very courteous staff, lovely accommodations, can't wait to return!

Reviewed on Feb 22, 2026

The Lodge at Primland, Auberge Collection
Comfort Inn Martinsville

Comfort Inn Martinsville

3 out of 5
378 Commonwealth Blvd W Martinsville VA
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $119 total per night from Mar 1 to Mar 2
$119 total
Mar 1 - Mar 2
Total with taxes and fees
6.8/10 (629 reviews)
The room was wonderful and everything was nice and clean

Reviewed on Feb 15, 2026

Comfort Inn Martinsville
Baymont by Wyndham Eden

Baymont by Wyndham Eden

2.5 out of 5
716 Linden Dr Eden NC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $94 total per night from Mar 3 to Mar 4
$94 total
Mar 3 - Mar 4
Total with taxes and fees
8.6/10 Excellent! (576 reviews)
The room was very clean. Check in and out was quick and easy. The only issue I had was that the breakfast was pretty well cleaned out at 9:00 am.

Reviewed on Feb 23, 2026

Baymont by Wyndham Eden
See all 268 properties in Mayo River
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mayo River Vacation Packages

Mayo River Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Piedmont Triad Intl. Airport (GSO)

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Frequently asked questions

How much does a Mayo River vacation package cost?
You'll find cheap prices from $307 on Expedia for your Mayo River getaway. However, a range of factors like the season, choice of hotel and length of stay will determine how much your vacation to Mayo River costs.
What are the cheapest months to go to Mayo River?
March, August and December are the best times to look for cheap Mayo River vacation packages. Choosing to travel in quieter periods means you'll typically find lower prices on flights and hotels.
How many days is enough for Mayo River?
Typically, a handful of days is enough to explore the top sights during your Mayo River vacation. However, if you prefer to have more time to chill out or go on day tours, consider extending your itinerary.
How to find the best Mayo River package deals?
Bagging a cheap Mayo River package deal is easy with Expedia. After you've entered your destination and trip dates under our "Packages" tab, set your maximum budget, add some filters and see what's available. You can personalize your search by "Amenities," "Property type," "Popular locations" and more. Order the results by "Price: low to high" to discover the most wallet-friendly Mayo River package deals. Want a simple trick to score even more savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Mayo River vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your car rental, flight and hotel into one great-value price and enjoy significant savings. You'll generally land a better deal than booking each component separately. And you'll still get the freedom to create a customized Mayo River vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Mayo River?
Secure incredible bargains by reserving your flights ahead of time with Expedia. If spontaneity is more your style, grab one of our last-minute deals for a spur-of-the-moment Mayo River adventure.
How to plan a trip to Mayo River?

  1. Choose when to travel: Check your schedule and pack your bags. Your favorite time of year and the type of activities available will also help you decide when to visit Mayo River.
  2. Calculate your budget: Ensure you have enough money to cover everything from transportation and meals to experiences and flights. Your accommodations will likely be the biggest expense during your trip to Mayo River.
  3. Use our trip planning tool to discover Mayo River: Research every part of your trip to Mayo River with this handy planner. Invite your family and friends to collaborate on a group trip, search for hotels or things to do and make bookings.
  4. Set the duration of your trip: Start by listing all the attractions you'd like to experience in Mayo River. Then, estimate how long you'll need at each, as well as any travel time.
  5. Bundle your bookings: With your travel dates in order, you can combine your hotels, car rental, flights and more into a customized Mayo River vacation package.
  6. Add on excursions and experiences: Have a look at our dedicated travel guide to find some exciting things to do in Mayo River. Book tickets or make reservations as soon as you can to save time and skip the hassle of looking for activities once you arrive.

Does Expedia offer Book Now, Pay Later Mayo River vacation packages?
Set off on your dream escape to Mayo River with our Book Now, Pay Later vacations. No need to save like crazy or wait until the next payday — we've teamed up with online lender Affirm to give you more financial flexibility. Our vacation packages with payment plans allow you to spread the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, you can easily stay on budget and snap up travel deals while they last.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.