Title: Mayo River Vacation Packages 2026 from $539 | Expedia.com [Mayo River Travel Guide](https://expedia.com/Mayo-River.dx553248635976006279)[Hotels in Mayo River](https://expedia.com/Mayo-River-Hotels.d553248635976006279.Travel-Guide-Hotels)[Vacation Rentals in Mayo River](https://expedia.com/Mayo-River-Vacation-Rentals.d553248635976006279.Travel-Guide-VacationRentals)[Flights to Mayo River](https://expedia.com/Cheap-Flights-To-Mayo-River.d553248635976006279.Travel-Guide-Flights)[Car Rentals in Mayo River](https://expedia.com/Car-Rentals-In-Mayo-River.d553248635976006279.Car-Rental-Guide) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Mayo River Vacations from $539 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## The Latest Mayo River vacation packages Price found within the past 48 hours. Click for updated prices. ![The Historic Magnolia House](https://images.trvl-media.com/lodging/73000000/72470000/72464600/72464524/2b9b9b34_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Historic Magnolia House $539 per person May 28 - May 31 found 15 hours ago Roundtrip non-stop flight included Tampa (TPA) to Greensboro (GSO) 6/10 (2 reviews) ![Arcade Kid Friendly Firepit Grill HotTub](https://images.trvl-media.com/lodging/113000000/112790000/112784800/112784705/2693b6fb_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Arcade Kid Friendly Firepit Grill HotTub Save 100% on your flight $1,513 per person May 28 - May 31 found 15 hours ago Roundtrip non-stop flight included Tampa (TPA) to Greensboro (GSO) No reviews ![Heated Pool King Bed Jacuzzi Bath Arcade](https://images.trvl-media.com/lodging/113000000/112790000/112787000/112786966/cf380342_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Heated Pool King Bed Jacuzzi Bath Arcade Save 100% on your flight $1,613 per person May 6 - May 9 found 1 day ago Roundtrip flight included New York (NYC) to Greensboro (GSO) 8/10 Very Good! (1 review) The house was very clean, comfortable, and nicely maintained, which we really appreciated during our stay. However, there were two downsides to be aware of. First, after booking, the owner asked us to pay an extra money for cleaning fee, even though it was not clearly listed in the Expedia booking details. I chose not to argue since I didn’t want to ruin our family trip, but future guests should expect additional charges. Second, privacy was an issue the owner lives in the basement, and it felt uncomfortable at times, especially with my child playing and moving around. Overall, it’s a nice property, but keep in mind the extra costs and limited privacy. Reviewed on Sep 30, 2025 ![KingBed PetFriendly Washer Dryer Sleep16](https://images.trvl-media.com/lodging/113000000/112770000/112763500/112763488/9faad64a_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### KingBed PetFriendly Washer Dryer Sleep16 Save 100% on your flight $2,030 per person May 28 - May 31 found 15 hours ago Roundtrip non-stop flight included Tampa (TPA) to Greensboro (GSO) No reviews ![Winston Sleeps 16 - 2 Kitchens Hot Tub](https://images.trvl-media.com/lodging/113000000/112770000/112766900/112766814/3d96fd97_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Winston Sleeps 16 - 2 Kitchens Hot Tub $736 per person May 6 - May 9 found 1 day ago Roundtrip flight included New York (NYC) to Greensboro (GSO) No reviews Don't see what you're looking for? See all available trips from Columbus to Mayo River [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-09/2026-04-16/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=GSO&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_553248635976006279) ### Discover the most popular places to visit in Mayo River ![The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.](https://images.trvl-media.com/place/553248621561864249/54558157-d5bc-4ba5-a77d-f9a917492c5a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Reynolds Homestead You can study the exhibits at Reynolds Homestead, a museum with a story of its own, during your travels to Patrick Springs. Amble around the area's forest or visit its spas. [](https://expedia.com/Reynolds-Homestead-Patrick-Springs.d553248621561864249.Vacation-Attraction) ## Mayo River Hotel Deals ![The Lodge at Primland, Auberge Collection](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/96761cd0_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Lodge at Primland, Auberge Collection 2000 Busted Rock Rd Meadows Of Dan VA $675 nightly $758 total Mar 18 - Mar 19 Total with taxes and fees 9.2/10 Wonderful! (28 reviews) They loved my dog Stella, giving her homemade treats and a cute bandana! Very welcoming everywhere at the property including the formal dining room, she was complimented the entire time on her exemplary behavior. The staff here is second to none, the room stunning as well as the lodge and the views. ... Reviewed on Mar 7, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F18%2F2026&endDate=3%2F19%2F2026&selected=3633184&PinnedHotelID=3633184&HadPinnedHotel=true®ionId=553248635976006279) ![Comfort Inn Martinsville](https://images.trvl-media.com/lodging/1000000/670000/665100/665072/012d74f6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Comfort Inn Martinsville 378 Commonwealth Blvd W Martinsville VA Fully refundableReserve now, pay when you stay $109 nightly $122 total Mar 15 - Mar 16 Total with taxes and fees 6.8/10 (631 reviews) Such kind service and large variety for breakfast! Our sports team had a lovely stay here Reviewed on Mar 1, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F15%2F2026&endDate=3%2F16%2F2026&selected=665072&PinnedHotelID=665072&HadPinnedHotel=true®ionId=553248635976006279) ![Scottish Inns Collinsville-Martinville](https://images.trvl-media.com/lodging/1000000/160000/154800/154773/9e55a796_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Scottish Inns Collinsville-Martinville 2357 Virginia Ave Collinsville VA Fully refundableReserve now, pay when you stay $52 nightly $58 total Mar 10 - Mar 11 Total with taxes and fees 6.8/10 (285 reviews) This place is run down and very low end. It’s cheap for a reason, but in this case it isn’t even worth the $60 a night. I’d rather be camping outside. Our room smelled like a wet dog, the shower barely worked, the cold water side of the sink faucet didn’t work, the wall mounted heater was really ... Reviewed on Mar 5, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F10%2F2026&endDate=3%2F11%2F2026&selected=154773&PinnedHotelID=154773&HadPinnedHotel=true®ionId=553248635976006279) [See all 270 properties in Mayo River](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026®ionId=553248635976006279) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Mayo River Vacation Packages ## Mayo River Essential Information | Language | English | | --------------- | ---------------------------------- | | Currency | U.S dollars | | Closest Airport | Piedmont Triad Intl. Airport (GSO) | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) 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![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations [](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Solo Vacations [](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click) ## Frequently asked questions ### How much does a Mayo River vacation package cost? ### What are the cheapest months to go to Mayo River? ### How many days is enough for Mayo River? ### How to find the best Mayo River package deals? ### Is it cheaper to book a Mayo River vacation as a package? ### When to book a vacation package to Mayo River? ### How to plan a trip to Mayo River? > 1. Choose when to travel: Check your schedule and pack your bags. Your favorite time of year and the type of activities available will also help you decide when to visit Mayo River. > 2. Calculate your budget: Ensure you have enough money to cover everything from transportation and meals to experiences and flights. Your accommodations will likely be the biggest expense during your trip to Mayo River. > 3. Use our [trip planning tool](https://www.expedia.com/why/trip-planning) to discover Mayo River: Research every part of your trip to Mayo River with this handy planner. Invite your family and friends to collaborate on a group trip, search for hotels or things to do and make bookings. > 4. Set the duration of your trip: Start by listing all the attractions you'd like to experience in Mayo River. Then, estimate how long you'll need at each, as well as any travel time. > 5. Bundle your bookings: With your travel dates in order, you can combine your hotels, car rental, flights and more into a customized Mayo River vacation package. > 6. Add on excursions and experiences: Have a look at our dedicated travel guide to find some exciting [things to do](https://www.expedia.com/Activities) in Mayo River. Book tickets or make reservations as soon as you can to save time and skip the hassle of looking for activities once you arrive. ### Does Expedia offer Book Now, Pay Later Mayo River vacation packages? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Critz Hotels ](https://www.expedia.com/Critz-Hotels.d6351114.Travel-Guide-Hotels) - [Cabin Rentals in Critz ](https://www.expedia.com/Critz-Cabins.d6351114-aaCabins.Travel-Guide-Accommodation) - [B&B in Critz ](https://www.expedia.com/Critz-Bed-And-Breakfast.d6351114-aaBedAndBreakfast.Travel-Guide-Accommodation) - [3 Star Hotels in Critz ](https://www.expedia.com/3Star-Critz-Hotels.s30-0-d6351114.Travel-Guide-Filter-Hotels) - [Vacation Homes in Critz ](https://www.expedia.com/Critz-Private-Vacation-Homes.d6351114-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Patrick Springs Hotels ](https://www.expedia.com/Patrick-Springs-Hotels.d3000460602.Travel-Guide-Hotels) - [Cabin Rentals in Patrick Springs ](https://www.expedia.com/Patrick-Springs-Cabins.d3000460602-aaCabins.Travel-Guide-Accommodation) - 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